Tumor Biology and Clinical Trials: The Richard and Hinda Rosenthal Foundation Award Lecture1

How Cancer Cells Evade Chemotherapy: Sixteenth Richard and Hinda Rosenthal Foundation Award Lecture1

Tumor biology and clinical trials: the Richard and Hinda Rosenthal Foundation Award Lecture.

Laboratory research is often described as basic and clinical research, prognostic or empirical. In this address, the point is made that research may be clinical or laboratory. Good clinical research may give important biological answers. Breast cancer clinical trials are decribed in terms of their biological interpretation. A list of significant biological questions that need answering are pres...

Basic Principles and Applications of Monoclonal Antibodies in the Management of Carcinomas: The Richard and Hinda Rosenthal Foundation Award Lecture1

The advent of hybridoma technology in 1975 (1) represented a quantum leap in the field of tumor immunology. For the first time, B-lymphocytes from immunized hosts could be immor talized by means of fusion with drug selected non-immunoglobulin secretor murine myeloma cells. These fused cell products could then be cloned and propagated indefinitely. The super natant fluids of cultures from litera...

Improving the Therapeutic Index in Breast Cancer Treatment: The Richard and Hinda Rosenthal Foundation Award Lecture1

Improving the relationship between desired and undesired effects of therapy, the therapeutic index, is a major goal ol cancer therapy. Clinical research pertinent to breast cancer treatment attempting to manipulate this therapeutic index is not restricted to studies in patients. Described herein is research in humans, mouse, machine, marrow, and molecule, concerned with either increasing care o...

Recent Advances in Head and Neck Cancer—Larynx Preservation and Cancer Chemoprevention: The Seventeenth Annual Richard and Hinda Rosenthal Foundation Award Lecture1

Head and neck cancer is a major public health problem. In the United States alone, approximately 43,000 new cases of head and neck cancer will be diagnosed and 11,000 persons will die of the disease in 1993 (1, 2). Worldwide, over 500,000 new cases of this cancer occur yearly, and the incidence is rising. Furthermore, despite intensive efforts in primary prevention, screening, and therapy, long...